ChemRisk performed a multi-faceted evaluation regarding manganese particulate emissions from a ferroalloy production facility in Marietta, Ohio in order to determine whether the emissions could impact the health of nearby residents.

The project involved addressing community concerns that arose subsequent to 1) a related ATSDR Health Consultation, 2) a study being conducted by the University of Cincinnati, and 3) air monitoring that was being conducted in Marietta and surrounding areas by the Ohio EPA (OEPA).

Each of these three evaluations was critically reviewed, and a focused literature review was conducted for manganese toxicity, bioavailability, biomarkers, and neurological endpoints. Additionally, an evaluation of potential community exposures was conducted using the OEPA air monitoring data, which considered information from the literature regarding exposures to manganese, and other potential sources of manganese in ambient air.

As a result of our analysis, we identified various limitations with each of the studies, and provided information to address the associated uncertainties, as well as the community’s concerns

Click on links below or articles to view abstract.

Manganese exposure among smelting workers.
Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley rats.
Current evidence and research needs regarding the risk of manganese-induced neurological effects in welders.
Manganese exposure among smelting workers: relationship between blood manganese-iron ratio and early onset neurobehavioral alterations.